Definition of Vicissitudes

changes (usually negative) in circumstances or fortune

Examples of Vicissitudes in a sentence

The vicissitudes of life led the once positive man to become cynical and negative.  🔊

Although they were once close, the vicissitudes of family strife caused the clan to grow apart.  🔊

Very few of the school’s founders were able to weather the vicissitudes of time and remain a part of the faculty.  🔊

Constant up and downs in power meant that the struggling country was not spared from political vicissitudes.  🔊

My mother is a tough woman and has been able to withstand the up-and-down vicissitudes of a difficult marriage.  🔊

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